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In contrast, free Cy5-siRNA rapidly degraded and disappeared from the blood, and almost no fluorescent signals of Cy5-siRNA can be detected in blood after 3 h (Fig

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It was discovered that these substances inhibited TNF--induced thymic stromal lymphopoietin (TSLP) expression at the transcriptional level through the suppression of mitogen-activated protein kinase (MAPK) signaling, which mediates the transcriptional activation of early growth response factor-1 (EGR-1) in human immortalized epidermal cells (HaCaT) keratinocytes