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Similar to Rac1, conditional KO of Cdc42 in the hippocampus also resulted in decreased spine density and impaired spine size enlargement in response to glutamate uncaging (Kim et al., 2014)

10.1007/s40495-015-0018-x 27 CaiJ.SunH.ZhengB.XieM.XuC.ZhangG.et al (2021)

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IGF-1 is first-line when a patient presents with signs of GH deficiency (increased visceral fat, low bone density, impaired quality of life after pituitary surgery or radiation) or GH excess (coarsened facial features, enlarged hands, new-onset diabetes)