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Third, the single-center cohort limits generalizability, and selection bias may exist due to the exclusion of patients lost to follow-up

After injection of 12 h, the rats exhibited pathological symptoms in their ankle joints, characterized by redness, swelling, heat, and pain

Immunofluorescence assay confirmed the colocalization of NK1R and STING in Caco-2 cells (Figure 8B, C), suggesting that SP might directly modulate the STING pathway