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In one non-limiting aspect of this invention, end-selection of a linear polynucleotide is performed using a general approach based on the presence of at least one end-selection marker located at or near a polynucleotide end or terminus (that can be either a 5' end or a 3' end)

These results indicated that the cytoskeleton structure was altered following IFFO1 depletion

Notably, the same signature is recapitulated in multiple ALS mouse models, where GPX4 loss in the spinal cord occurs early and universally during disease development [235]

Weight loss re-gainers and weight loss-retainers were defined by a cut-off of 25% BMI loss