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That is an issue because a dehydrated athlete will have more concentrated urine relative to a well-hydrated athlete, and so the concentration of any substances (prohibited or not) appearing in their urine will be higher, thus increasing the probability of an anti-doping rule violation being pursued against them simply because of their hydration status

However, patients enrolled in most related studies reported painful DPN resulting in sleep problems and more severe pain leading to worse sleep quality [11, 32]