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This reaction is central to one-carbon metabolism, which supports DNA synthesis, red blood cell formation, and methylation reactions throughout the body

An initial pilot study showed that supplementation of children with autistic disorder with 800 g folinic acid and 1,000 g betaine per day for two months normalised homocysteine levels and improved GSH:GSSG [46]

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the first was based on a methodology developed using the Prism for in vitro studies and the second was based on the combination of QUADAS-2 and the JBI Evidence Synthesis Manual to assess the quality of the papers, as shown in Tables 2 and 3 [26]