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doi: 10.1016/j.jinsphys.2025.104860 260 ZhangRZhongJLiYLiMZhangJHuQet al

Factors that influence the number of sessions include: Ink colors Skin type Size and location Age of the tattoo Ink depth and density Many patients begin to notice visible fading after just a few treatments, with continued improvement after each session

doi: 10.1016/j.biomaterials.2015.05.028 109 ZhangXTLiuYHLiuWChenLQJinMJGaoZGet al

To test this idea, artificial microRNA (amiRNA) constructs targeting two different loci of 3 UTR of -GLUTAMYLCYSTEINE SYNTHETASE ( GSH1 , the rate-limiting enzyme required for glutathione biosynthesis) were generated (amiGSH1-1 and amiGSH1-2) and introduced into the smt15-1 mutant (Figure 3A)