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The purification using column chromatography on silica gel was performed to afford the compound 4 as a yellow solid (226 mg, yield of 78%)

Zn reaches physiologically high but transient concentrations in synaptic cleft

The grayscale values were analyzed and statistically processed using ImageJ software

Identifying these differences through advanced molecular and imaging techniques could help tailor ferroptosis-targeted interventions to specific subphenotypes, optimizing therapeutic efficacy