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Nicotine Replacement Therapy Nicotine replacement therapy (NRT) replaces the nicotine a person would normally get from tobacco (cigarettes, vaping/e-cigarettes, snuff/chewing tobacco) with something safe like the nicotine patch, gum or lozenge.(2) These products help people get past cravings while they learn how to live life tobacco free.(2) NRT can include over-the-counter medications like the nicotine patch, gum or lozenge, and prescription medications like the nicotine nasal spray or nicotine inhaler.(2) Combination NRT means combining a long-acting type of nicotine replacement, the nicotine patch, with a short-acting medication such as the gum, lozenge, inhaler, or nasal spray

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