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Relationship to expression profiles in other COPD studies In order to show that the gene expression signature of regional emphysema severity is present in larger cohorts of patients with earlier stages of disease, we used GSEA to examine the relationship between genes associated with regional emphysema severity in this dataset and genes associated with COPD phenotypes in other cross-sectional studies [611]

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Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion