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Food Hydrocolloids, 126 , Article 107441

A literature review examining the relationship between glycyrrhiza dosage and pseudoaldosteronism found that the mean incidence was 1.0% at a daily dose of 1 g, increasing to 1.7% at 2 g/day, 3.3% at 4 g/day, and reaching 11.1% at 6 g/day (MANTANI et al., 2015)

These effects are dose-dependent: low to moderate doses mainly enhance adaptive stress responses through mild Nrf2 activation, while higher doses of concentrated alcoholic extracts produce stronger pharmacological effects by directly suppressing NF-B and intensifying Nrf2 activation [33]

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