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The GPX1 SOD2 PARP1 SIRT1 cascade is one of the clearest mechanistic chains connecting antioxidant genetics to NAD+ depletion and the broader aging program

Vitamin E supplementation at various levels alters cytokine production by thymocytes during retrovirus infection causing murine AIDS

Specifically, CSCs dependent on OXPHOS have been observed to maintain robust ATP production even when glycolytic intermediates or glucose are scarce, allowing them to withstand radiotherapy or chemotherapy that targets rapidly proliferating, highly glycolytic cells

Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis