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98 Although berberine has been studied in human clinical trials and shown to have several metabolic benefits, concerns about long-term use of berberine have been raised on the basis of certain preclinical studies

Signal Transduct Target Ther 8(1):248

Outside the liver, some enzymes in the urea cycle have strong crosstalk with other metabolic pathways to rewire urea cycle intermediates to support the survival and proliferation of tumor cells (Keshet et al., 2018