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However, this leads to complete loss of the CAR-T cells ( Applied to SSTR-targeted therapy for pancreatic NENs, a promising regulated approach has been proposed

A study (Houtman et al., 2019) shows that BECN1 deficiency enhances IL-1 and IL-18 release from microglia, causing aberrant neuroinflammation and neurodegeneration, potentially linked to high mobility group box 1 (HMGB1) secretion