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46,7375 It is therefore suggested that metformin use may be an agent of iatrogenic potential inducing peripheral neuropathy exacerbation in individuals with T2DM who have depressed Vitamin B12, as a result of elevated fasting methylmalonic acid (MMA) and tHcy levels

[1] demonstrated that CSE knock out (CSE KO) mice fed with atherogenic diet displayed a 30-fold increase in ICAM-1 expression and increased atherosclerotic plaque size compared to wild type control

[PubMed: 28156151] 479

It also explores "the flow state" -- that state you can get to through extreme athletic performance or artistic activities but is the most difficult to pin down