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At 68 weeks, participants receiving the cagrilintide-semaglutide combination achieved a mean body weight reduction of 22.7% under the trial product estimand

and SURMOUNT-4 Investigators (2023)

This makes it one of the very few injectable veterinary products that can be safely administered to dairy cows, milking ewes, and laying hens without any requirement to discard milk, hold back slaughter, or withdraw eggs from sale

This unique enzymatic mechanism directly couples sirtuin activity to cellular NAD+ availability, making these longevity proteins exquisitely sensitive to cellular energy status and NAD+ levels