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Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice

This causes an increase in the production of additional inflammatory cytokines, which in turn causes the inflammatory responses to become more intense (Kelley et al

Hedges' g effect values of 0.20, 0.50 and 0.80 respectively represent small, medium and large effects ( Meta-analysis was performed using R Studio's Metafor package ( I 2 statistics for quantification and Cochran's Q for statistical significance test to evaluate heterogeneity

Moreover, surface-bound plasmin may counteract complement as demonstrated for diverse human pathogenic bacteria 8,49,62,63