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An increase in NCC may indicate an acute pathological risk, even when total copper levels are within the normal range [261]

Overexpression of human GPX1 modifies Bax to Bcl-2 apoptotic ratio in human endothelial cells

Conclusion: Collectively, our results uncover CLDN1 as a driver for CCA invasion and metastasis by modulating tumor cell signaling, EMT and the tumor microenvironment