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These findings align with known molecular alterations induced by hyperglycemia and are consistent with reported changes in diabetic bone tissue (Wongdee and Charoenphandhu 2011), underscoring the effectiveness of this ex vivo model in elucidating comprehensive and translatable alterations associated with diabetic bone disease (Arajo et al

Aliment Pharmacol Ther 50:901910 Tye-Din JA, Stewart JA, Dromey JA, Beissbarth T, van Heel DA, Tatham A, Henderson K, Mannering SI, Gianfrani C, Jewell DP et al (2010) Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease