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Interestingly, increased reliance on mitochondrial metabolism to exit the quiescent state is also associated with significant alterations to the morphology, mass, distribution, and overall membrane potential of the mitochondrial network (Beckervordersandforth et al., 2017)

This review provides a comprehensive overview of the clinical features, pathophysiology, prognosis, epidemiology, histopathological characteristics, genetic and immunological mechanisms, as well as current treatments and therapeutic approaches, thereby offering the latest insights into this complex disease

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