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Molecular challenges in activating the NRF2 antioxidant response Even though KEAP1 shows potential as a molecular target for the rescue of NRF2 defects, targeting KEAP1 for therapeutic purposes remains a challenge

thus, Mn plays a key role in phosphorylation, hydrolysis, carbon metabolism, decarboxylation, and the oxidative stress response 10

According to several in vitro studies, low dose of ionizing radiation exposure stimulates p53 pathway, cell cycle arrest, apoptosis, immune system enhancement, etc

[44] investigated the relationship between AGEs and AF by measuring plasma AGE levels and serum concentration of soluble receptors for AGEs (sRAGE) in 97 patients, including both groups of diabetic and non-diabetic patients