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As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively

Statistics and reproducibility All data were processed, analyzed, and visualized using GraphPad Prism 9 Software (version 9.5.1) (GraphPad Software, Inc.)

Reduction of FAAH concentration resulted in an increase in the level of AEA, which in turn alleviated colitis by activating CB receptors

AOD-9604 is administered via subcutaneous injection into fatty tissue, with the abdominal region being the preferred site