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Thus, in the most metabolically active tissues such as renal cells, hepatocytes, endocrine cells, endothelial cells, and neurons, low GSH levels should be expected to be directly correlated with worse cellular function and early cell death

The biological half-lifes of TAM and its metabolites in blood or brain were determined after reaching maximum by non-linear regression (one-phase decay, GraphPad Prism 7, GraphPad Software Inc., La Jolla CA, USA)

This rapid return to baseline clotting risk explains why patients can experience strokes or clotting events within days of stopping therapy