Original Article First-line biologic therapy selection highly impacts ulcerative colitis outcomes: results from the APPETISER study Diari MBaye 1 , Marianne Hup 2 , Marie Dodel 1 , Mava Bazoge 1 , Bruno Pereira 3 , Anthony Buisson 1,4 DOI: Published online: February 10, 2026 1 Service dHpato-Gastroentrologie, CHU Clermont-Ferrand, Inserm, 3iHP, Universit Clermont Auvergne, Clermont-Ferrand, France 2 Hepato-Gastroenterology and Digestive Oncology Department, CHU Grenoble Alpes, Institute for Advanced Biosciences, CNRS UMR 5309-INSERM U1209, Universit Grenoble Alpes, Grenoble, France 3 DRCI, Unit de Biostatistiques, CHU Clermont-Ferrand, Universit Clermont Auvergne, Clermont-Ferrand, France 4 Inserm U1071, M2iSH, USC-INRA 2018, F-63000, Universit Clermont Auvergne, Clermont-Ferrand, France Correspondence to Anthony Buisson, Service dHpato-Gastroentrologie, CHU Clermont-Ferrand, 1 place Aubrac, Clermont-Ferrand 63100, France
Yes, in some cases
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This approach circumvents both gastric degradation and hepatic metabolism, allowing rapid mucosal absorption and minimizing systemic exposure