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Yet, that is what happens when a person with symptomatic B12 deficiency experiences that she or he needs more frequent supplementation than once every 3 months

(as long as the causative factor for B 12 deficiency persists, therapy should be continued) Evidence from animal and human studies shows that B 12 also has neuroprotective and anti-inflammatory properties, 15 and intervention studies in humans have reported beneficial effects of better B 12 status or B 12 therapy in multiple sclerosis, 16 Parkinsons disease, 17 myalgic encephalomyelitis, 18 autism, 19 and (administering very high doses of methylcobalamin) in amyotrophic lateral sclerosis

What does all this data say

[26] DNA methylation is involved in the functioning of genes and is an essential epigenetic control mechanism in mammals