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Surprisingly, very similar prediction results with AUROC = 0.80 was established in this external validation cohort, suggesting that these microbiome features can be used to distinguish and predict human TMAO producer phenotypes from carnitine metabolism and have adequate potential to be applied in different populations

10.1016/j.cbi.2008.10.052 Chem

The core insight behind Carnifuel is that different carnitine forms benefit different physiological systems and deliver carnitine to different tissues with different mechanisms no single form covers all of them

Fatty acids must first be activated (attached to coenzyme A) before entering mitochondria