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Insofar as aminoacrylate takes seconds to many minutes to be nonenzymatically converted to pyruvate and ammonia, the possibility exists that proteins and other macromolecules in the vicinity of the aminoacrylate-generating enzymes will be severely damaged. It is of considerable interest, therefore, that nature has evolved enzymes (RidA proteins) that are widely distributed and that considerably accelerate the rate of conversion of aminoacrylate to pyruvate and ammonia, thereby lessening the impact of enzyme-generated aminoacrylate (Ernst et al., 2014, Niehaus et al., 2014, Niehaus et al., 2015)

Garlic also inhibits CYP2E1 enzymes, which produce free radicals and cause oxidative stress-induced damage and inflammation [10, 65]

The clinical data here is more robust than for any other nutrient

J Uro FDA Drug Safety Communication: 5-alpha reductase inhibitors (5-ARIs) may increase the risk of a more serious form of prostate cancer