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These PK limitations underscore why clinical applications of redox-active OSCs are currently most promising in topical, gastrointestinal, or mucosal delivery systems rather than systemic formulations

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Variants of other genes involved in homocysteine metabolism, such as MTHFR, 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), MTR reductase (MTRR) and metabolism of cobalamin associated C, also contribute to homocysteine toxicity

Treatment may include whole-bowel irrigation with polyethylene glycol electrolyte solution if radiographic evidence of retained metal (toys, coins, paint chips) is present