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The report highlights early metabolic studies, selected clinical trials, and certain double-blind placebo-controlled investigations that examined markers such as: blood sugar regulation insulin sensitivity cholesterol levels impaired glucose tolerance adipose tissue activity fat release and lipolytic activity While these studies generated interest in AOD-9604 as a potential anti-obesity drug candidate , the report stresses that no authority recognizes it as an active treatment for obesity, weight loss, or human use and emphasizes that it remains designated strictly for research use

Obstetricians have prescribed it for morning sickness since the 1940s, and the American College of Obstetricians and Gynecologists still recommends it as a first-line treatment for pregnancy-related nausea

If the goal is to taper off retatrutide, the more common approach is to maintain the CJC/Ipa layer during and after the retatrutide taper to support recomposition

A healthcare professional may still recommend the medication if they feel the benefit outweighs the risk to the developing fetus