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One step at a time: endoplasmic reticulum-associated degradation

68(Suppl 1) :S28-38

In severe cases, renal transplantation and liver transplantation may be necessary for the management of the condition [11]

According to the astrocyte-to-neuron lactate shuttle (ANLS) hypothesis, astrocytes are the primary producers of lactate which is then shuttled to neurons via monocarboxylate transporters (MCTs) and metabolized [89]