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A mild deficiency may have no symptoms, but a more severe or prolonged deficiency can exhibit the following: Microcytic anemia Skin conditions Depression Confusion Lowered immunity Certain conditions can increase the risk of developing a deficiency by interfering with the absorption of vitamin B6: Kidney disease Autoimmune intestinal disorders like celiac disease, ulcerative colitis, and Crohns disease Autoimmune inflammatory disorders such as rheumatoid arthritis Alcoholism Toxicity It is quite unlikely to reach a toxic level of vitamin B6 from food sources alone

BrenneisenP.SteinbrennerH.SiesH.2005Selenium, oxidative stress, and health aspects

Thus, immune responses to life saving therapeutics such as Enzyme Replacement Therapies (ERT) for Lysosomal Storage Diseases and Factor VIII for Hemophilia A constitute a severe risk necessitating mitigating strategies