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These findings indicate that compared to other administration routes of vitamin B12, acupoint injection improves neurological function in patients with DN without increasing adverse events and economic burden, suggesting that it may be the optimal administration route for vitamin B12

41 In addition, the specific knockout or ablation of INSR in livers prevents insulin suppression of hepatic glucose production (HGP), 42,43 suggesting a direct role for INSR in hepatic IR

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