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2025;192:R2943

Planning your supply For a standard 20-week escalation from 2.5 mg to 15 mg: Weeks 1 to 8: one 30 mg vial (10 mg + 20 mg = 30 mg used) Weeks 9 to 12: one 30 mg vial (30 mg at 7.5 mg/week) Weeks 13 to 16: one 30 mg vial (30 mg at 10 mg/week, used in 3 weeks) Weeks 17 to 20: two 30 mg vials (60 mg at 12.5-15 mg/week) Total: approximately 4 to 5 vials for a 20-week protocol

The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline (semaglutide injection 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide injection 0.7%, placebo 0.4%)