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Boosting NAD + via the de novo pathway through Trp supplementation is not as popular, as quinolinic acid generated from Trp conversion is neurotoxic, and kynurenines have immunomodulatory roles 58

Pernicious anemia is a B12 deficiency anemia caused by the lack of intrinsic factor.[ref] What causes the lack of intrinsic factor in pernicious anemia