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The formation of colonies was further impaired in ADH5 GCLM cells compared to ADH5 -single knockout counterparts, thus revealing an independent contribution of GSH biosynthesis and ADH5 to this phenotype (Fig

The current study clarified a novel mechanism by which the ROS/HO1/GPX4 axis mediates the protection against cisplatin-induced renal tubular epithelial cell ferroptosis for both BNIP3-mediated and PINK1-PARK2-mediated mitophagy [58]