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(109) found that cashew protein hydrolysate inhibited the production of pro-inflammatory cytokines in the brain of rats with arterial occlusion-induced cerebral is chaemia, and by modulating the function of lipid metabolism, its modulation of serum cholesterol, TG, and LDL, and elevation of HDL, greatly improved spatial memory in rats

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were the first to describe increased whole gut permeability in patients with alcohol abuse without significant liver disease, measured by a 24 h urinary excretion of 51 Cr-EDTA, which was confirmed by increased uptake of macromolecules (inulin, EDTA and cyanocobalamin) ex vivo in jejunal biopsies (145)