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The beneficial effect of exercise on gut microbiota is contributed by several mechanisms, including an increase in bacterial diversity (usually associated with favorable health outcomes), an increase in fecal short chain fatty acids (SCFA), an increase in the proportion of health-promoting bacterial species (e.g., Faecalibacterium prausnitzii , and Akkermansia muciniphila ), and a decrease of obesity and metabolic diseases-related bacteria (e.g., Eubacterium rectale and Clostridium coccoide a) (Estaki et al., 2016

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The present randomized, placebo-controlled trial sought to study the effects of high-dose intravenous vitamin C in adults with sepsis on vasopressor therapy in the ICU

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