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(h)GSH Depletion Negatively Influences Nodule Development, While Exogenous Glutathione Application Promotes Infection and Defense Responses in sym33-3 Mutants and the Maturation of Infected Cells in sym40-1 Mutants The expression levels of GSH1 , GSHS , Cyp15a, TPP , PR1 , and PR10 were upregulated in (h)GSH-depleted wild-type roots with nodules (Figure 7)

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Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes