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In locally advanced disease, such combinatorial approaches may theoretically enhance treatment responses in preclinical models, which could provide a conceptual basis for less invasive interventions

Front Cell Neurosci 7:39

TSHR-CAR-T was constructed by incorporating the first extracellular domain (21-413aa) of TSHR, fused with the CD8 transmembrane and intracellular signaling domain (4-1BB), which can recognize and effectively eliminate TRAb-producing B lymphocytes both in vitro and in vivo ( 4.7 Type 1 diabetes First-generation CD3--CAR T cells, expressing the 2-microglobulin component of MHC I and targeting the anti-InsB15-23-H-2Kd TCR, significantly reduced insulitis and protected non-obese diabetic (NOD) mice from T1DM ( in vitro , due to the broad expression of the Hpi2 antigen across multiple cell types

In addition to the identification of druggable disease mechanisms, better ways to stratify ALS patients and identify disease progression markers are urgently needed to better define specific disease stages and/or response to therapy