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Methods 60 , 4654 (2013)

dementia currently affects more than 55.2 million individuals worldwide, and this number is projected to reach 78 million by 2030 from the World Alzheimer Report 2021

For proteomics Differentially expressed proteins were determined by applying Permutation Test with unadjusted significance level of p 90% sequence homology with CYPA10

In addition, macrophages secrete sphingomyelinase, which has been reported to act synergistically with LPL to promote binding of LDL and lipoprotein (a) (Lp(a)) to vascular smooth muscle cells (VSMC) and the extracellular matrix promoting their retention in the artery (239,240)