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Description

Histological analysis Rat tissues were serially sectioned at 4 m thicknesses and then mounted on slides for further study

Despite these positive indications, human studies are limited

Mouse models lacking Parkin or PINK1 develop motor deficits and dopaminergic neuron loss when subjected to mitochondrial stress, particularly in combination with the mutator mouse model, which accumulates mtDNA mutations due to POlG dysfunction [60]