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Together, both works demonstrate that CYP2D6 and CYP2C19 polymorphisms significantly influence antidepressant plasma exposure, which directly affects pharmacodynamic mechanisms underlying efficacy and side-effect profiles

425,426,427 These innovative medicines delve deeper into AD mechanisms and present diverse target choices, holding the potential to halt or reverse AD progression

In 1972, I was asked by Jacques Monod, then head of the Institut Pasteur, to create a research unit in the newly created Department of Virology of the Institute

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