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Smoking also reduces saliva production that normally helps neutralize refluxed acid and clear it back to the stomach

(2025) 93:e0051224

Gastrointestinal Studies BPC-157 was originally isolated from gastric juice, and much of the early research focused on GI models: Cytoprotection: Multiple rodent studies have demonstrated protective effects on gastric mucosa in lesion models (Sikiric et al., 1993, 1994)