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These symptoms can significantly reduce a persons quality of life and, if not treated, can cause life-threatening complications

Witte AB, Anestl K, Jerremalm E, Ehrsson H, Arnr ES (2005) Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

PMID: 10223088

A practical application of the combined model would be to predict the concentration and exposure time required to cause toxicity via overwhelming GSH metabolism as a function of quinone metabolism