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Given its ability to inhibit MCT1 in tumors expressing high MCT1 levels, AZD3965 could enhance drug penetration across the BBB and modulate the tumor microenvironment, warranting further investigation in glioblastoma models (Table 3)

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This strategy is a more direct measurement using dansyl fluorescence properties that is not affected by conjugation, whereas quantification using mass spectrometric responses is not quantitatively reliable

Ethics declarations Ethics approval and consent to participate The subjects consented to participate in the study, the clinical study was carried out following guidelines for human studies with the approval of the Ondo State Health Research Ethics Committee (OSHREC), Ondo State (OSHREC 22/3/2021/316)