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How much of their reputation is backed by evidence

A recent 2024 review also suggests probiotics may be useful in treating GERD in children, though the study notes that more research is needed to confirm this

Br J Pharmacol 155:185197 Ren SX, Shen J, Cheng AS, Lu L, Chan RL, Li ZJ, Wang XJ, Wong CC, Zhang L et al (2013) FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells

This includes, at a minimum, fasting blood glucose and ideally IGF-1 levels to ensure they remain within a safe and effective range for the study's objectives