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Anisimov, Khavinson and colleagues (2003), publishing in Biogerontology , reported a lifespan study in female outbred Swiss-derived SHR mice receiving 1 g/mouse of Epitalon subcutaneously on five consecutive days each month from age three months to natural death (n = 54 per arm)

39 : e103954

Despite the intestinal barrier being designed to limit the translocation of luminal components, certain factors disrupt its integrity including genetic predisposition, gut microbiota dysbiosis and environmental factors such as those present in food and oral therapeutics (Fig