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IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells

Step 1 Advisory Panel Vote: The outside panel assesses each of the seven compounds and votes on whether they should be eligible for compounding under 503A

R 3 and R 4 are independently selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, C1-C12 substituted alkynyl, C3-C8 cycloalkyl, C3-C8 substituted cycloalkyl, C6-C10 aryl, C6-C10 substituted aryl, C3-C8 heterocycloalkyl, C3-C8 substituted heterocycloalkyl, C4-C10 heteroaryl, C4-C10 substituted heteroaryl, +CH(R a )OPO(OY)2, ^CH(R a )OPO(OY)(OH) and 3 and R 4 together are bonded to form a fused bicyclic ring system or a spirocyclic ring system

doi: 10.1016/j.peptides.2006.04.025