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In addition, knocking down ACTL6A increased the expression levels of prostaglandin-endoperoxide synthase 2 (PTGS2) (Supplementary Fig 3b), which is a ferroptosis marker 30,46

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all P -values are reported in Supplementary Table 1 and source data are available in the Dryad repository doi:10.5061/dryad.905qfttvz)

Ethnic differences and varied environmental, lifestyle, cultural, socioeconomics and nutritional factors might explain inconsistent results from different studies

It is also worth noting that in the case of MCI, stability in cognitive performance, and not necessarily improvement, could represent a positive outcome