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Experimental data on animal models have suggested that GIP suppresses peripheral arterial remodeling, thus showing an anti-atherosclerotic activity, by acting on receptors in the heart and vessels." Outcomes of clinical trials The first clinical trial to test the clinical efficacy of TZP was the SURPASS program, a six-stage trial conducted on three separate cohorts Japanese (SURPASS-J), Asian-Pacific (SURPASS-AP), and the cardiovascular outcome trial (SURPASS-CVOT)

Ethics declarations Ethics approval and consent to participate Due to the observational nature of this case report, which does not involve any interventions or experimental procedures, formal ethical approval was not required

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Know the timeline Most patients notice appetite suppression within the first one to two weeks on tirzepatide